Chronic lymphocytic leukaemia

Read about the main treatments for chronic lymphocytic leukaemia (CLL), including chemotherapy and stem cell transplants.

Treatment for chronic lymphocytic leukaemia (CLL) largely depends on what stage the condition is at when it's diagnosed.

You may just need to be monitored at first if it's caught early on. Chemotherapy is the main treatment if it's more advanced.

Treatment can often help keep CLL under control for many years.

It may go away after treatment initially (known as remission), but will usually come back (relapse) a few months or years later and may need to be treated again.

This page covers:

Stages of CLL

Monitoring early-stage CLL

Chemotherapy for more advanced CLL

Stem cell or bone marrow transplants

Other treatments for CLL

Deciding against treatment

Clinical trials for CLL

Stages of CLL

Doctors use "stages" to describe how far CLL has developed and help them determine when it needs to be treated.

There are three main stages of CLL:

  • stage A – you have enlarged lymph glands in fewer than three areas (such as your neck, armpit or groin) and a high white blood cell count
  • stage B – you have enlarged lymph glands in three or more areas and a high white blood cell count
  • stage C – you have enlarged lymph glands or an enlarged spleen, a high white blood cell count, and a low red blood cell or platelet count

Stage B and C CLL are usually treated straight away. Stage A generally only needs to be treated if it's getting worse quickly or starting to cause symptoms.

Monitoring early-stage CLL

Treatment may not be needed if you don't have any symptoms when you're diagnosed with CLL.

This is because:

  • CLL often develops very slowly and may not cause symptoms for many years
  • there's no benefit in starting treatment early
  • treatment can cause significant side effects

In these cases, you will normally just need regular visits to your doctor and blood tests to monitor the condition.

Treatment with chemotherapy will usually only be recommended if you develop symptoms, or tests show that the condition is getting worse.

Chemotherapy for more advanced CLL

Many people with CLL will eventually need to have chemotherapy. This involves taking medication to keep the cancer under control.

There are a number of different medicines for CLL, but most people will take three main medications in treatment cycles lasting 28 days.

These medicines are:

  • fludarabine – usually taken as a tablet for three to five days at the start of each treatment cycle
  • cyclophosphamide – also usually taken as a tablet for three to five days at the start of each treatment cycle
  • rituximab – given into a vein over the course of a few hours (intravenous infusion) at the start of each treatment cycle

Fludarabine and cyclophosphamide can usually be taken at home. Rituximab is given in hospital, and sometimes you may need to stay in hospital overnight.

A number of different medicines can also be tried if you can't have these medicines, you've tried them but they didn't work, or your CLL has come back after treatment.

These include bendamustine, chlorambucil, ibrutinib, obinutuzumab and prednisolone (a steroid medication).

Side effects of treatment

The medicines used to treat CLL can cause some significant side effects, including:

Most side effects will pass once treatment stops. Let your care team know if you experience any side effects, as there are some treatments that can help.

Read more about the side effects of chemotherapy.

Stem cell or bone marrow transplants

Stem cell or bone marrow transplants are sometimes used to try to get rid of CLL completely, or control it for longer periods.

Stem cells are cells produced by the spongy material found in the centre of some bones (bone marrow) that can turn into different types of blood cells, including white blood cells.

A stem cell transplant involves:

  • having high-dose chemotherapy and radiotherapy to destroy the cancerous cells in your body
  • removing stem cells from the blood or bone marrow of a donor – this will ideally be someone closely related to you, such as a sibling
  • transplanting the donor stem cells directly into one of your veins

This is the only potential cure for CLL, but it's not done very often as it's an intensive treatment and many people with CLL are older and not well enough for the benefits to outweigh the risks.

The initial treatment with chemotherapy and radiotherapy can place a significant strain on your body and cause troublesome side effects.

There's also a risk of serious problems after the transplant, such as graft versus host disease. This is where the transplanted cells attack the other cells in your body.

Read more about what happens during a stem cell transplant and the risks of a stem cell transplant.

Other treatments for CLL

There are also a number of other treatments that are sometimes used to help treat some of the problems caused by CLL, particularly if you can't have chemotherapy or it doesn't work.

These include:

  • radiotherapy to shrink enlarged lymph glands or a swollen spleen
  • surgery to remove a swollen spleen
  • antibioticsantifungals and antiviral medications to help reduce your risk of picking up an infection during treatment
  • blood transfusions to provide more red blood cells and platelets (clotting cells) if you experience severe anaemia or problems with bleeding and bruising
  • immunoglobulin replacement therapy – a transfusion of antibodies taken from donated blood that can help prevent infections
  • injections of medication called granulocyte-colony stimulating factor (G-CSF) to help boost the number of white blood cells

You may also need additional treatment for any complications of CLL that develop.

Deciding against treatment

As many of the treatments for CLL can have unpleasant side effects that may affect your quality of life, you may decide against having a particular type of treatment.

This is entirely your decision and your treatment team will respect any decision you make.

You won't be rushed into deciding about your treatment, and before making a decision you can talk to your doctor, partner, family and friends.

Pain relief and nursing care will still be available as and when you need it.

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